Outline
- Abstract
- Keywords
- 1. Introduction
- 2. Polysaccharides
- 3. Polysaccharide-Based Nanoparticles
- 3.1. Covalently Crosslinked Polysaccharide Nanoparticles
- 3.2. Ionically Crosslinked Polysaccharide Nanoparticles
- 3.3. Polysaccharide Nanoparticles by Polyelectrolyte Complexation (pec)
- 3.3.1. Negative Polysaccharides
- 3.3.2. Negative Peptides
- 3.3.3. Polyacrylic Acid Family
- 3.3.4. Others
- 3.4. Self-Assembly of Hydrophobically Modified Polysaccharides
- 3.4.1. Linear Hydrophobic Molecules
- 3.4.2. Cyclic Hydrophobic Molecules
- 3.4.3. Polyacrylate Family Molecules
- 4. Perspective
- References
رئوس مطالب
- چکیده
- کلیدواژه ها
- 1.مقدمه
- 2.پلی ساکاریدها
- 3. نانو ذرات مبتنی بر پلی ساکارید
- 3.1 نانو ذرات پلی ساکاریدی از طریق کمپلکس سازی پلی الکترولیت (PEC)
- 3.1.1 پلی ساکارید ها منفی
- 3.1.2 پپتیدهای منفی
- 3.1.3 خانواده ی اسید پلی آکریلیک
- 3.1.4 بقیه موراد
- 3.2 گردایش خود به خودی پلی ساکارید های اصلاح شده به طور آبگریز
- 3.2.1 مولکولهای آبگریز تناوبی
- 3.2.2 مولکولهای خانواده ی پلی آکریلات
- 4. چشم انداز
Abstract
Natural polysaccharides, due to their outstanding merits, have received more and more attention in the field of drug delivery systems. In particular, polysaccharides seem to be the most promising materials in the preparation of nanometeric carriers. This review relates to the newest developments in the preparation of polysaccharides-based nanoparticles. In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crosslinking, polyelectrolyte complex, and the self-assembly of hydrophobically modified polysaccharides.
Keywords: Drug delivery system - Nanoparticle - Polysaccharide4. Perspective
As reviewed above, so many nanoparticle drug delivery systems have been prepared. It can be predicted that, more nanoparticle drug delivery systems will emerge. Until now, these nanoparticles are generally investigated in terms of their physicochemical properties, drug-loading ability, in vitro toxicity, and comparatively simple in vivo tests. The more important issues, such as the specific interaction of these nanoparticles with human organs, tissues, cells, or biomolecules, the effect on human’s metabolism brought by the nanoparticles, and the wider application of these nanoparticles for drug delivery, etc. await further deep study, which will be focused on in the near future.